Cannabis Research!

The Cannabis plant has been used for recreational, healing and spiritual reasons for thousands of years, all over the world. One of the first documented recommendations for the medical use of cannabis was done by emperor Shen Nung almost 5000 years ago. According to legend, Shen Nung is the father of Chinese medicine and pharmacology. He sought out and investigated hundreds of herbs documenting many of them in his treatise On Herbal Medical Experiment Poisons ( tasting 365 herbs and dying from a toxic overdose in the end.. ) and is still worshiped by native Chinese medicine men.  He is thought to have introduced acupuncture to China and promoted a plant based diet for good health.

He is often referred to as the Yan Emporer and the literal meaning of his name translates to “the divine farmer”.

We have named one of our strains in hounor of him, CBD Divine, a regular indica 1:1 CBD/THC strain.

Princess MaGu, the immortal Hemp Maiden, the Goddess of Cannabis. She served cannabis for healing and longlivety and got rewarded by becoming a Taoist Xian. ( spiritually immortal; transcendent; super-human; celestial being )

Cannabis have been found in several ancient graves all over the world and it has been assumed that the findings were for medicinal use.

Chinese medicine man

He was found in a 2,700-year-old grave in the Gobi Desert with nearly two pounds of still-green plant material. It has been recognized as the world’s oldest cannabis.

Cannabis found in prehistoric tomb in Pakistan.

The various caves composing the settlement would have been inhabited for more than 2500 years during neolithic period.

The Oseberg find from Viking times in Norway .

Two women were buried in a mound in the county of Vestfold, Norway, around the year 850 in a splendid ship. They had both cannabis seeds and a pice of hashis with them.

Dr. W. B. O’Shaughnessy did studies on Indian Hemp in the late 1800’s

Many medical marijuana patients may know that Dr. William Brooke O’Shaughnessy (1809-1889) introduced cannabis to modern Western medicine, ( even thou it had already found it’s way before ) but know little else of this Irishman’s extraordinary life.

There are many cannabis findings all around the world, and probably many that we will never know about. If you are interested, there is lots of information on the web, a quick search away!

Cannabis was a widespread medicine commonly used up until the early 1900’s in most parts of the world. Then the war on drugs started, and soon cannabis was illegal across all nations. Cannabis soon became marijuana, the drug that made you crazy. And this propaganda sadly sill lives on in many places around the world. Resulting in laws that are doing great damage to the development of cannabis as a medicine and not to mention the people that utilize it.

Several hundreds of studies on cannabis has so far been done already and it will be very interesting to see all research is being conducted now after some dark ages of prohibition. Exiting times ahead!

http://www.nature.com/bjc/journal/v95/n2/abs/6603236a.html http://www.ncbi.nlm.nih.gov/pubmed/11479216 http://www.jneurosci.org/content/21/17/6475.abstract http://jpet.aspetjournals.org/content/308/3/838.abstract Read More: http://www.whydontyoutrythis.com/2013/09/42-medical-studies-that-prove-cannabis-can-cure-cancer.htm

We will try to keep as many scientific studies of cannabis THC/CBD as possible available on this page. If you come across any that are still not listed here, please send them to us so we can add them. The more research we can offer, the more knowledge we can spread. We also thank ProjectCBD for gathering so many studies at one place and all the researches, lab technicians and scientists that are working trough the stigma to provide us with very valuable information. Cannabis Research!

Medical cannabis & general benefits

• Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action. (PubMed2008)
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Anxiety

• Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug(PubMed)
• Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa (PubMed)
• Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients (PubMed)
• Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder (PubMed)
• Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation (PubMed)
• Effects of cannabidiol (CBD) on regional cerebral blood flow (PubMed)
• The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors (PubMed)
• The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system (PubMed)
• Plant-based medicines for anxiety disorders, part 2: A review of clinical studies with supporting preclinical evidence (PubMed)

Alzheimer’s

• The therapeutic potential of the endocannabinoid system for Alzheimer’s disease(PubMed)
• Endocannabinoid signalling in Alzheimer’s disease (PubMed)
• A molecular link between the active component of marijuana and Alzheimer’s disease pathology (PubMed)
• Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells (PubMed)
• The Potential Therapeutic Effects of THC on Alzheimer’s Disease (PubMed)
• Cannabinoids for the treatment of dementia (PubMed)
• Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression (PubMed)
• Cannabidiol: A promising drug for neurodegenerative disorders? (PubMed)
• Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer’s disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition(PubMed)
• The role of the endocannabinoid system in Alzheimer’s disease: facts and hypotheses (PubMed)
• The role of phytochemicals in the treatment and prevention of dementia (PubMed)
• Cannabinoids for the treatment of dementia (PubMed)
• Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+ Cells Through PPARγ Involvement (PubMed)
• Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic (Pub Med)
• Can Marijuana Prevent Alzheimer’s? (Next Avenue)

Addiction

Cancer div studes

• Cannabidiol as potential anticancer drug (PubMed)
• Cannabidiol inhibits angiogenesis by multiple mechanisms (PubMed)
• The inhibitory effects of cannabidiol on systemic malignant tumors (PubMed)
• Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1 (PubMed)
• Marijuana fights cancer and helps manage side effects (Daily Beast)
• Endocannabinoids in endocrine and related tumours (PubMed)
• A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells (PubMed)
• TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer (PubMed)

• Targeting CB₂-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling

• Cannabis and Cannabinoids (PDQ®)Laboratory/Animal/Preclinical Studies (Natinal Cancer Institute)
• Cannabinoids: potential anticancer agents Manuel Guzmán

– Lung Cancer

• Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1C (PubMed)
• COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells (PubMed)
• Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells (PubMed)
• Media ignored expert’s shocking findings that marijuana helps prevent lung cancer(O’Shaughnessy’s)

– Prostate / Colon Cancer

• Towards the use of non-psychoactive cannabinoids for prostate cancer (PubMed)
• In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines (Scirp.org)
• Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent (PubMed)
• Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer (PubMed)
• Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol (PubMed)

– Breast Cancer

• Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma (PubMed)
• Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy (PubMed)
• Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis (PubMed)
• Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells (PubMed)
• Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration (PubMed)

• Cannabis and Cannabinoids (PDQ®)Laboratory/Animal/Preclinical Studies (Natinal Cancer Institute)

– Glioblastoma / Brain

• Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival (PubMed)
• Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines (PubMed)
• Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas (PubMed)
• Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism (PubMed)
• Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target (PubMed)
• Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents (PubMed)
• Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect (PubMed)
• Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme (PubMed)
• The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model

– Leukemia

• Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression (PubMed)
• Cannabidiol-Induced Apoptosis in Human Leukemia Cells (PubMed)

– Skin Cancer

• Anticancer activity of anandamide in human cutaneous melanoma cells (PubMed)

– Kaposi Sarcoma

• Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpes virus-infected endothelium (PubMed)

– Cancer ralated pain

• Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain (PubMed)
• Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial (PubMed)
• Marijuana extract helps prevent chemo pain (UPI)

Chrons & stomack problems

Depression

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