Children with epilepsy, who are we to deny them efficient aid?

 

Over the last years numerous people have come forth showing the incredible effects CBD have had on their children that suffer from various forms of epilepsy. Many have had to break the law or move far away from family and friends to places where they can legally obtain quality CBD products.  Many also try CBD products of lesser quality and don’t get the best results right away , due to the illegality and the mountains of industrial hemp products out there that vary very in quality.  So as a costumer you really have to know what questions to ask and what paperwork to expect to be shown from the supplier.

Here is a letter from Parents4Pot that they published years ago to try guide parents the right way:

 

 

EPILEPSY CBD

As respected members of the cannabis community, the undersigned groups and activists support full spectrum cannabis legislation and treatment for children with autism and seizure disorders. We agree that experience and research show proper and effective treatment requires the combination only the full cannabis plant can provide. We also agree that we need to support other organizations and activists who stand with us and concur that medical cannabis, by definition, includes the entire plant and all its chemical compounds.
As more parents learn that cannabis can help their children with autism and seizure disorders, it has become necessary to point out that the upshot of CBD only legislation and companies that produce CBD only products are giving what may be false hope to families who have exhausted other avenues of treatment.
We believe it is vital to understand the importance of using the entire cannabis plant as part of their solution. Parents who are worried that their children are “getting high” need to know that cannabis does not have the same psychoactive effect on the brain of a child with severe epilepsy or autism as it does on the average person. It actually works to slow the neurons that are firing so rapidly down, creating a healthier brain not a “high” brain. It is equally important for parents to know that they can give their children full plant cannabis without getting them “high.” Ingesting whole plant cold extract cannabis delivers non- psychoactive, non-psychotropic effects. This is an essential factor in building up the system that enables THC and CBD to work. It also allows the incorporation of the myriad beneficial components that cannabis provides.
The truth is that many parents who have tried CBD only treatments for their children with autism and epilepsy report no success or reduction in symptoms. They are forced to go to the black market to get the medicine they need. In fact, parents who are using straight THC as a rescue medication for their children’s seizures are seeing great results. Their children are cognitive and coherent instead of high and out of commission for a whole day.
Industrial hemp does not contain the amount of THC or CBD needed to make an effective treatment for epilepsy or autism. Also important to remember is that these CBD producers are unregulated; there is no proof that they are really providing what they promise. That, along with the lack of results are two good reasons to consider other options.
Parents, please feel free to contact the groups listed below to learn more about the differences between full plant and CBD only cannabis treatments to make a more informed decision. Your child’s life depends on it.

 

Websites:
www.parents4pot.org

We believe people should be able to grow their own plants and make their own CBD rich products at home safely. Which is one of the reasons we have developed all our CBD rich strains.  For those looking for low THC, high CBD, we recommend our CBD Therapy

Growing yourself is the most cost effective way of getting CBD products as buying a lot of tinctures can be expensive for low income households and you will always be sure what you actually have. And hopefully soon people will also be able to get high quality CBD product made form low THC, high CBD cannabis flowers over the counter at their local CBD shops, health food stores or even pharmacies.

 

 

For more info and studies regarding cannabinoids and epilepsy,  visit:

 

ProjcetCBD

 

CBD-rich cannabis extract as compared to single-molecule CBD

 

 

CB1 & CB2 + GPR55? Another receptor for cannabinoids?

Story from: CannabisNow

 

Is there a Third Cannabinoid Receptor?

 

We have long known about the two cannabinoid receptors: CB1 and CB2.  Now there is growing awareness of a third such receptor that was identified in 2007.

This receptor, GPR55, may be key to understanding a wide spectrum of therapeutic applications for cannabinoids — and especially CBD.

The GPR55 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.

 

 

A scientific study published last year was the latest to focus the research community on the potential of the GPR55 receptor, which is now known to be the third identified receptor in the human endocannabinoid system. The study found a role for the receptor in the use of CBD to treat Dravet syndrome, a rare and severe form of epilepsy.The research team from the University of Washington at Seattle noted that they saw potential to “extend the scope of CBD treatment to autistic-like behaviors, and provide initial mechanistic insights into CBD’s therapeutic actions,” according to the abstract in the Proceedings of the National Academy of Sciences (PNAS).In the human endocannabinoid system, cannabinoid receptors are the specialized protein molecules that interact with the active cannabis compounds in the human body. Since the 1990s, scientists have known about the receptors CB1 and CB2, but research is continuing to emerge about the GPR55 receptor and the role it appears to play in the endocannabinoid system as another unique cannabinoid receptor. 

The Recent History of GPR55 Receptor Research

It was a 2007 study published by the National Center for Biotechnology Information (NCBI) that first identified what was until then known as the “orphan receptor” GPR55  — meaning its function had not yet been determined — as a “novel cannabinoid receptor.” In the years since then, evidence has been mounting that the GPR55 receptor could explain the actual biological mechanisms for many of the benefits reported by cannabis users.

A 2009 study published by PNAS found a role for the GPR55 receptor in regulating osteoclast function — that is to say, bone formation and healing. A 2016 study published by the NCBI found a similar role in controlling inflammation.

Most impressive was a 2015 overview published by Frontiers in Pharmacology, which found that two orphan receptors as well as the “deorphanized” GPR55 “may be promising therapeutic targets, with diverse physiological roles,” ranging from gastrointestinal to bone disorders.

The Science Behind the GPR55 Receptor

The GPR55 receptor — the 55th in the series of G-protein-coupled receptors that also include CB1 and CB2 — is found in the brain and gastrointestinal tract. The G stands for guanine, which is a nucleotide base, meaning it is one of the so-called “building blocks” of DNA. Guanine is associated with the G proteins because of how these receptors interact with cells. The receptor “receives the chemical and sends messages to cells such as neurons,” according to Robert Sindelar, chief science officer and head of product development at BAS Research — a Berkeley, California-based licensed manufacturer of “white-label” cannabis products.

“The endocannabinoid system has been a black box for many years, partially due to federal restrictions on research,” Sindelar told Cannabis Now. “Basically, we’re starting to find out: How does this stuff do this? People with seizures are being affected by CBD. How does this actually happen? With the new work on GPR55, scientific research is catching up with what traditional knowledge and anecdotal evidence have documented for hundreds of years.”

As an example, Sindelar points to Dravet syndrome: “It’s a rare disease that was basically thought to be untreatable. Many sufferers have found their only relief in taking a steady regimen of CBD. Now they’ve found the mechanism or mode of action by which CBD sends a message to something in the brain that tells a child suffering from Dravet syndrome to either have a seizure or not.”

Because there is a growing body of evidence around the GPR55 receptor, including the 2017 study which discovered the GPR55 receptor’s role in treating Dravet syndrome, Sindelar says there is more pressure on the academic community to continue researching the GPR55 receptor as a potential target for epilepsy treatment, especially in terms of how it interacts with CBD.

And Sindelar sees these studies as ultimately having political ripples. “Research is eliminating the scientific mystery about what people see in practice, or anecdotally,” he said. “This could provide the body of evidence we need to deschedule these chemicals. In many ways, I feel it’s inevitably leading to a change in the way cannabinoids are federally classified to allow further investigation into these things. That opens [research] up to federal funding.”

 

 

 

Study on GPR55
Published online 2013 Jul 1.

Orphan G protein receptor GPR55 as an emerging target in cancer therapy and management

 

Conclusion:

 

“Because of its cannabinoid sensitivity and similar tissue localization, GPR55 can explain some of the effects observed that are not mediated by the canonical cannabinoid receptors Cb1 and Cb2. To date, LPI has been described as the endogenous GPR55 ligand, but endocannabinoids AEA, 2-AG, and the agonist O-1602 can also activate it. Therefore, GPR55 is likely the first LPI:  receptor described. …….

……Additional studies to elucidate the role of endocannabinoid GPR55 ligands in GPR55 physiology and pathophysiology are also warranted, as endocannabinoids have been shown to play a role in inflammation, cancer, liver disease, and inflammatory disorders of the intestinal tract, to name a few. In conclusion, GPR55 has emerged as a promising candidate for the development of novel anticancer therapeutic strategies.”

 

 

 

Cannabis, a ‘Relatively Safe Drug’ UN declares

 

For the first time ever, the World Health Organization met last week to review the safety of cannabis.

What will this mean for the fight for legalization worldwide? Well it’s to soon to say, but at least we hope that this is a step in the right direction. We at CBD Crew have always said the fight is not over before people all around the world can safely grow their own plants and also have access to dispensaries if they are in a situation where they can not grow their own. Lets see what happens now and keep sharing knowledge so this will happen sooner than later!

 

 

Story from Herb:

 

The United Nations’ drug committee found that marijuana is a “relatively safe drug,” noting that millions of people worldwide are already using it to manage a multitude of medical conditions.

The findings could impact a recommendation the agency is preparing to the UN on the “need for and level of international control” over cannabis. Marijuana prohibition is in force almost worldwide under international drug treaties originally dating back to 1961.

Worldwide, an estimated 183 million adults used cannabis in 2015, according to the report. Weed is cultivated in 135 countries and is the “most widely illicitly produced drug worldwide.”

The UN agency conducted a survey of 953 medical marijuana patients from 31 nations. Most of them said they’d used cannabis-based medicines for years. Most were also under the supervision of a physician. But a majority said they’d also tried cannabis before getting a doctor’s recommendation.

 

Used most often for pain

 

Cannabis, in various forms, is used most often to control back pain, sleep disorders, anxiety, depression, post-injury pain, and multiple sclerosis, according to the report. Pain, sleep disturbances, and anxiety were the three conditions most commonly treated with cannabis.

An estimated 2.2 million patients use cannabis medicinally in the United States. Pain is the most often cited qualifying condition. Pain also ranked high among cannabis patients in Israel and Canada. Meanwhile, 30 percent of cannabis patients in the United Kingdom reported using the herb to treat multiple sclerosis. (Cannabis-infused Sativex spray is commonly prescribed for M.S. in Great Britain.)

The committee, interestingly, pointed to a “wealth of preclinical literature” indicating cannabinoids “reduce cancer cell proliferation” and inhibit “cancer cell migration and angiogenesis in numerous cancer cell types.” This seems to be an area of great promise, with more research to come.

Then there are the recreational cannabis users. An estimated 3 to 5 percent of people globally have tried marijuana for non-medical reasons, according to the UN report. Interestingly, two studies examined by the report found no significant differences between those who use cannabis medically and nonmedical users.

One study, however, found medical patients used more cannabis daily than recreational consumers. Medical patients were more likely to be in poorer health than recreational users. But the study found they also had lower levels of both alcoholism and nonprescription drug use.

A nurse lights a cannabis cigarette for a patient at the Hadarim nursing home on March 09, 2011 in Kibutz Naan, Israel. In conjunction with Israel’s Health Ministry, The Tikun Olam company is currently distributing cannabis for medicinal purposes to over 1800 people in Israel. (Photo by Uriel Sinai/Getty Images)

Research lagging

 

The UN report noted that scientific research into cannabis is inadequate. There’s plenty of public interest, but very few clinical trials have been done, due largely to the legal strictures of prohibition.

“Barriers to research in the USA include the difficulty of navigating through several federal agencies (including the aforementioned DEA, FDA) as well as research ethics boards and local and state oversight concerns,” according to the report.

The UN report, interestingly enough, also noted problems in quality control from the current single source of cannabis for scientific research in the US. All federal cannabis is grown at one farm on the campus of The University of Mississippi in Oxford, Miss.

“The current international policies on cannabis use are outdated and are having a detrimental impact on patients in the US and worldwide,” said Steph Sherer, executive director of Americans for Safe Access (ASA). “These policies do not reflect the reality of over 30 countries globally that have passed medical cannabis laws.”

 

 

UN Chief Wants to Decrim All Drugs

 

UN Secretary-General António Guterres in March gave a speech supporting the decriminalization of all drugs. His comments went counter to the UN’s top narcotics officials. They’d released a report earlier the same week criticizing cannabis legalization around the world.

“Current efforts have fallen short of the goal to eliminate the illicit drugs market,” said Guterres in a video message. “We can promote efforts to stop organized crime while protecting human rights, enabling development and ensuring rights-based treatment and support. I am particularly proud of the results of the reforms I introduced in Portugal when I was prime minister almost 20 years ago.”

Guterres, as prime minister of Portugal, introduced the decriminalization of all drugs in that nation in 2001. The policy is viewed as a success and has been praised by advocates around the world. Overdose deaths, HIV infections, and even overall use has reduced under decrim in the country.

 

 

52 people sickened by fake CBD oil in Utah, that is not good news!

It’s sad to read when people don’t get the help they need form just weak cbd products, but when they even get sick, that is just horrible.

Getting good CBD products with a entourage effect ( not just only CBD, but more cannabinoides ) is very important for those willing to give CBD a try.  There is so many different qualities in oils these days, it can be hard to find a good one for your needs. That is why we often recommend making one your self, if you have the possibility. Then you know what goes into your oils. But as many can’t grow for themselves, we have some recommendations.  Always ask for cannabinoid profile, shown in % of CBD and other cannabinoids,  not just mg pr ml numbers. And you want the actual lab test, not just a fancy layout on a web page. Also ask if  it has a natural terpene profile, again a real lab test and if it’s organically grown. Any company should have this easily available for you, if they don’t, maybe look for another company.

Thou it’s important to remember, that if CBD products don’t work for you, a cannabis product with both CBD & THC might be what you need.

“In a report released Thursday, the Centers for Disease Control and Prevention found that synthetic products falsely labeled as cannabidiol, or CBD, sickened as many as 52 people from October through January.”

 

The CDC report this week found that more than half of the 52 possible cases either tested positive for a synthetic compound called 4-CCB or reporting using a product called Yolo CBD Oil, samples of which contained the synthetic instead of authentic CBD. Efforts to determine what company manufactures Yolo CBD Oil were not successful.”

 

Read the whole story HERE: 52 people sickened by fake CBD oil in Utah

 

 

 

Getting rid of bugs without using chemicals? Here are some ideas!

Need to get rid of bugs?

 

We always urge people to grow as organic as possible to get a clean healthy product, but sometimes bugs can force you to bring out the chemicals. So before it goes to far and the bugs are everywhere, maybe try something organic, cheap and homemade recipes before bringing out the heavy artillery. Also, when it comes to cannabis, you want to get your plant bug free before putting them on flowering, to be sure there is no bugs in those buds. As the flowers grow, you do not want to spray them with anything, especially not chemicals.

But you might have some great ingredients for a natural pesticide just sitting around at your home, just waiting to be tried out.

Here are some homemade ways to get rid of bugs, give them a try!

 

 

1. Neem

Ancient Indians highly revered neem oil as a powerful, all-natural plant for warding off pests. In fact, neem juice is the most powerful natural pesticide on the planet, holding over 50 natural insecticides. This extremely bitter tree leaf can be made in a spray form, or can be bought from a number of reputable companies.

To make your own neem oil spray, simply add 1/2 an ounce of high quality organic neem oil and ½ teaspoon of a mild organic liquid soap (f.eks Dr. Bronners Peppermint) to two quarts of warm water. Stir slowly. Add to a spray bottle and use immediately.

 

2. Salt Spray , Himalayan crystal salt

For treating plants infested with spider mites, mix 2 tablespoons of Himalayan Crystal Salt into one gallon of warm water and spray on infected areas.

3. Mineral oil

Mix 10-30 ml of high-grade oil with one liter of water. Stir and add to spray bottle. This organic pesticide works well for dehydrating insects and their eggs.

 

4. Citrus Oil and/or Cayenne Pepper Mix

This is another great organic pesticide that works well on ants. Simply, mix 10 drops of citrus essential oil with one teaspoon cayenne pepper and 1 cup of warm water. Shake well and spray in the affected areas.

 

5. Soap, Orange Citrus Oil & Water

To make this natural pesticide, simply mix 3 tablespoons of liquid Organic Castile soap with 1 ounce of Orange oil to one gallon of water. Shake well. This is an especially effective treatment against slugs and can be sprayed directly on ants and roaches.

 

6. Eucalyptus oil

A great natural pesticide for flies, bees and wasps. Simply sprinkle a few drops of eucalyptus oil where the insects are found. They will all be gone before you know it.

 

7. Onion and Garlic Spray

Mince one organic clove of garlic and one medium sized organic onion. Add to a quart of water. Wait one hour and then add one teaspoon of cayenne pepper and one tablespoon of liquid soap to the mix. This organic spray will hold its potency for one week if stored in the refrigerator.

 

8. Chrysanthemum Flower Tea

These flowers hold a powerful plant chemical component called pyrethrum. This substance invades the nervous system of insects rendering them immobile. You can make your own spray by boiling 100 grams of dried flowers into 1 liter of water. Boil dried flowers in water for twenty minutes. Strain, cool and place in a spray bottle. Can be stored for up to two months. You can also add some organic neem oil to enhance the effectiveness.

9. Tobacco Spray

Tobacco ( try using organic tobacco )

Just as tobacco is not good for humans, tobacco spray was once a commonly used pesticide for killing pests, caterpillars and aphids. To make, simply take one cup of organic tobacco (preferably a brand that is organic and all-natural) and mix it in one gallon of water. Allow the mixture to set overnight. After 24-hours, the mix should have a light brown color. If it is very dark, add more water. This mix can be used on most plants, with the exception of those in the solanaceous family (tomatoes, peppers, eggplants, etc.)

 

10. Chile pepper / Diatomaceous Earth

Grind two handfuls of dry chiles into a fine powder and mix with 1 cup of Diatomaceous earth. Add to 2 liters of water and let set overnight. Shake well before applying.

 

– Dr. Edward F. Group III, DC, ND, DACBN, DCBCN, DABFM

 

The tips are form GlobalHealingCenter.com

 

 

 

If you have some easy recipes for making your own organic pesticides, or have any experiences with these methods, do let us know 🙂

 

World Health Organization ( WHO ) recognizing CBD as therapeutic.

World Health Organization ( WHO )  is recognizing the need for opening up to medical cannabis for patients and for all scientists.

 

We are exited to hear what the new report in May 2018 will conclude.

 

This report said:

Cannabidiol (CBD)

 

There is increased interest from Member States in the use of cannabis for medical indications including for palliative care. Responding to that interest and increase in use, WHO has in recent years gathered more robust scientific evidence on therapeutic use and side effects of cannabis and cannabis components.

 

To that end, the ECDD did an initial review of a cannabis compound called cannabidiol (CBD). Recent evidence from animal and human studies shows that its use could have some therapeutic value for seizures due to epilepsy and related conditions.

 

Current evidence also shows that cannabidiol is not likely to be abused or create dependence as for other cannabinoids (such as Tetra Hydro Cannabinol (THC), for instance). The ECDD therefore concluded that current information does not justify scheduling of cannabidiol and postponed a fuller review of cannabidiol preparations to May 2018, when the committee will undertake a comprehensive review of cannabis and cannabis related substances.

 

 

Read the whole story here:
WHO recommends the most stringent level of international control for synthetic opioid carfentanil

 

They are soon starting again, the 2017 Medical Cannabis Bike Tour!

In case you don’t know about this wonderful group of people, you need to know!

 

The 2017 Medical Cannabis Bike Tour

 

Who are they, why are they cycling around?

Every year they set out on an epic journey to cycle 420km through beautiful European scenery over 3 days.

They raise sponsorship money to fund independent clinical research by a team of scientists studying the medical qualities of cannabis.

The message is clear, cannabis studies should be done for the people, so that we can get public results. So much of cannabis studies are done in secrecy or by the pharmaceutical industry, with results that are not public for everybody to read.  Or just done looking for negative effects, not all the amazing positive effects we now  know cannabis has.

So the solution was, gather the money from the public and give directly to the best qualified scientist out there!

Many companies and people in the cannabis community has for several years now sponsored the bike rides. And we at CBD Crew have been proud sponsors the whole time. We have not gotten on a bike yet, but maybe in the future! Until then, we support the great people that join the beautiful ride!

Here is a clip from fist day last year, how nice does this look?  Are you a biker? Maybe join!

 

 

Next Medical Cannabis Bike Tour  starts 3rd of October, if you want to join or help sponsor, or just read up on  this great initiative, more info here!

 

Medical Cannabis Bike Tour 2017

 

Uruguay just started selling strains that has been created in collaboration with CBD Crew!

Yes, that is right. Last week two strains, that have been created in collaboration with Uruguayan government & CBD Crew, started being sold in the pharmacies in Uruguay. Alfa I and Beta I are their names. We hope they will be of help to many people!

 

Here is a story about it all! 

(  it’s in Spanish, but hopefully the translation will be done soon )

 

                          Jaime in Uruguay

 

 

 

 

 

The endocannabinoid system, why is it not common knowledge?

The endocannabinoid system( ECS), one of the very important systems in our body.

It was found in the late eighties buy researchers studying the effect of cannabis on the body, which led to the discovery of the CB1 and CB2 receptors. Yet we seem to know so little about it in general today 30 years later.

Does your doctor even know?  If not, why?

 

“Back in 2013, David B. Allen MD commissioned a survey in which all the medical schools in the US were asked whether they included the ECS within their syllabus. Only 13% were found to teach it in any way, with Dr. Allen declaring that “research and education of medical students involving the ECS is being intentionally restricted by politics.”

( source: The Cannapedia )

 

So it seems like for now, we have to educate ourselves and maybe our doctors as well on this issue.

 

Here you can read many stories on how the Endocannabinoid system works and what it helps regulate. Project CBD.

 

Studies show that not only do we benefit from adding cannabinoids to our body, but not doing so could also be damaging to the body itself.  As debated in this study:

Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?

Luckily now there is a lot of great information online about the ECS and here is some for you to look trough right now!